Clinical manifestation and perceived symptoms of walking-related performance fatigability in persons with multiple sclerosis

Fatigue and walking difficulties are common impairments activity limitations in persons with multiple sclerosis (PwMS). Walking fatigability (WF) can be measured by a Distance Walked Index is defined as decline distance of 10% or more during the six-minute test (6MWT). However, clinical manifestation perceived symptoms related to still not well documented. Forty-nine PwMS [Expanded Disability Status Scale (EDSS) ≤6] 28 healthy controls (HC) performed 6MWT. The severity 11 was rated on visual analogue scale 0–10 before, immediately after, 10, 20 30 minutes after 6MWT means symptom inventory. Short motor impairment screening tests at baseline together other descriptive measures were performed. Twenty pwMS categorized WF group disabled (EDSS: 4.16 ± 1.41) than non-walking (n = 29, EDSS: 2.62 1.94). showed exacerbations several MS, where most returned within 10 test. significantly muscle weakness gait impairment, balance problems, experienced an increase spasticity, pain dizziness Our findings that higher presenting WF, temporally Future research quantitative measurement recommended.